کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6077409 | 1203534 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heterogeneity of Response to Biologic Treatment: Perspective for Psoriasis
ترجمه فارسی عنوان
ناهمگونی واکنش به درمان بیولوژیک: چشم انداز برای پسوریازیس
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
چکیده انگلیسی
Psoriasis treatment responses are affected by patient characteristics. However, the literature does not contain reviews of factors that affect the response to biologic therapies. We therefore performed a comprehensive literature search to identify papers describing demographic, lifestyle, and clinical factors associated with response to biologic drug therapy in psoriatic patients. We found that age, gender, ethnicity, alcohol consumption, smoking, geographic location, age at diagnosis, duration and severity of psoriasis, and baseline C-reactive protein levels did not consistently affect response to biologic psoriasis therapy. However, increased body mass index (BMI) appears to adversely affect responses. It might therefore be valuable to include BMI as a stratification variable in future studies of psoriasis therapies and to consider a patient's weight or BMI when selecting a systemic psoriasis treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 134, Issue 1, January 2014, Pages 18-23
Journal: Journal of Investigative Dermatology - Volume 134, Issue 1, January 2014, Pages 18-23
نویسندگان
Emily Edson-Heredia, Kimberly L. Sterling, Carlos I. Alatorre, Gebra Cuyun Carter, Rosirene Paczkowski, Victoria Zarotsky, Tomoko Maeda-Chubachi,