کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117259 | 1217176 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of the C-type lectin-like domain family-16A (CLEC16A) gene polymorphisms with acute coronary syndrome in Mexican patients
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کلمات کلیدی
DAMPsACSPAMPsHMGB1damage-associated molecular patterns - الگوهای مولکولی مرتبط با آسیبpathogen-associated molecular patterns - الگوهای مولکولی مرتبط با پاتوژنSusceptibility - حساسیتAcute coronary syndrome - سندرم کرونری حادGenome-wide association studies - مطالعات مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومGenetic polymorphisms - پلیمورفیسم ژنتیکیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The CLEC16A gene has an important role in the immune activation and regulation inflammatory. This gene encodes to C-type lectin domain that is involved in the recognition of DAMPS. The aim of this study was assess the CLEC16A gene polymorphisms in the risk of developing ACS in a group of patients. Four rs12708716, rs12917716, rs6498142 and rs9925481 (positions 146529 A > G, 155804 G > C, 47905 C > G and 64135 C > T, respectively) single nucleotide polymorphisms of CLEC16A gene were analyzed by TaqMan assays in a group of 452 patients with ACS and 456 healthy controls. The analysis was performed on the total group of individuals and then in groups of men and women separately. Under co-dominant model adjusted by cardiovascular risk factors the rs12708716 (146529 A > G) and rs12917716 (155804 G > C) polymorphisms were significantly associated with decrease risk of ACS in men (OR = 0.16, PCo-dom = 0.027 and OR = 0.37, PCo-dom = 0.016, respectively). In summary, our data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 162, Issue 2, Part B, December 2014, Pages 247-251
Journal: Immunology Letters - Volume 162, Issue 2, Part B, December 2014, Pages 247-251
نویسندگان
Gilberto Vargas-Alarcon, Julian Ramirez-Bello, Javier Angeles-Martinez, Jose Manuel Rodriguez-Perez, Nonanzit Perez-Hernandez, Carlos Posadas-Romero, Esteban Jorge-Galarza, Wendy Angelica Ocampo-Arcos, Claudia Obil-Chavarria, Jose Manuel Fragoso,