Killer artificial antigen-presenting cells deplete alloantigen-specific T cells in a murine model of alloskin transplantation

► Killer artificial antigen-presenting cells (KaAPCs) were developed. ► Alloskin graft survival was prolonged for 6 days by administration of KaAPCs. ► A 60% decrease of H-2Kb antigen-alloreactive T cells was demonstrated. ► Intact immune function, including antitumor activity, was maintained.