Gender-based blood transcriptomes and interactomes in multiple sclerosis: Involvement of SP1 dependent gene transcription

► Gender-based transcriptomics uncovers distinct changes in gene expression in women and men with MS. ► MS is associated with alterations in the quantity and in the quality of the human sex-specific genes. ► Female and male MS gene profiles share biological processes and interactomes. ► Female and male MS gene profiles are under the control of the transcription factor SP1. ► Blockade of SP1 dependent gene transcription ameliorates EAE.