کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6126026 | 1592677 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isogeneic MSC application in a rat model of acute renal allograft rejection modulates immune response but does not prolong allograft survival
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کلمات کلیدی
TMAMSCsRTXhpfTMA, Thrombotic microangiopathy - ترومبوتیک میکروانژیوپاتیHUS - خانهAllograft rejection - رد آلوگرافتMesenchymal stromal cell - سلول استروما MesenchymalMesenchymal stromal cells - سلولهای استرومایی مزانشیمی یا سلول های بنیادی مزانشیمیHemolytic uremic syndrome - سندروم اورلیمی همولیتیکSide effect - عوارض جانبیImmune modulation - مدولاسیون ایمنیhigh power field - میدان قدرت بالاKidney transplantation - پیوند کلیهRenal transplantation - پیوند کلیهserum creatinine - کراتینین سرمSCR - یکسوساز کنترلشده با سیلیکون
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Isogeneic MSC application in a rat model of acute renal allograft rejection modulates immune response but does not prolong allograft survival Isogeneic MSC application in a rat model of acute renal allograft rejection modulates immune response but does not prolong allograft survival](/preview/png/6126026.png)
چکیده انگلیسی
Application of mesenchymal stromal cells (MSCs) has been proposed for solid organ transplantation based on their potent immuno-modulatory effects in vitro and in vivo. We investigated the potential of MSCs to improve acceptance of kidney transplants in an MHC-incompatible rat model including isogeneic kidney transplantation (RTx) as control. MSCs were administered i.v. or i.a. at time of transplantation. No immunosuppression was applied. Renal function was monitored by serum-creatinine, histopathology, immunochemistry for graft infiltrating cells and expressions of inflammatory genes. We demonstrated the short-term beneficial effects of MSC injection. In the long term, however, MSC-related life-threatening/shortening events (thrombotic microangiopathy, infarctions, infections) were evident despite decreased T- and B-cell infiltration, lower interstitial inflammation and downregulated inflammatory genes particularly after i.a. MSC injection. We conclude that i.a. MSC administration provides efficient immunomodulation after allogeneic RTx, although timing and co-treatment strategies need further fine-tuning to develop the full potential of powerful cell therapy in solid organ transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 29, Issues 1â4, December 2013, Pages 43-50
Journal: Transplant Immunology - Volume 29, Issues 1â4, December 2013, Pages 43-50
نویسندگان
M. Koch, A. Lehnhardt, X. Hu, B. Brunswig-Spickenheier, M. Stolk, V. Bröcker, M. Noriega, M. Seifert, C. Lange,