کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6126109 | 1221210 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of early rapid corticosteroid reduction on cell-mediated immunity in kidney transplant recipients
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کلمات کلیدی
intracellular ATPanti-thymocyte globulinHTNTACCRFCITATGCGNMMFCNIPRAGFRATP - آدنوزین تری فسفات یا ATPPanel reactive antibody - آنتی بادی واکنش پانلhuman leucocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیTacrolimus - تاکرولیموسDiabetes mellitus - دیابت قندیAcute rejection - رد حادcold ischemia time - زمان سرد ایسکمیcytomegalovirus - سیتومگالوویروسCMV - سیتومگالوویروسHypertension - فشار خون بالاmycophenolate mofetil - مایکوفنولات موفتیلcalcineurin inhibitor - مهار کننده کالسینورینChronic renal failure - نارسایی مزمن کلیهGlomerular filtration rate - نرخ فیلتراسیون گلومرولیImmune response - پاسخ یا واکنش ایمنیTransplantation - پیوندKidney transplantation - پیوند کلیهchronic glomerulonephritis - گلومرولونفریت مزمن
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
While being helpful in the prevention and treatment of acute rejection (AR) in kidney transplant patients, corticosteroids have many side effects associated with their long-term use. It is reasonable to minimize these adverse effects without affecting their benefits. In this prospective trial, we investigated the effects of early rapid corticosteroid reduction on the cell-mediated immunity, measured by the Cylex® Immune Cell Function Assay, the incidence of AR and infection and the allograft function after kidney transplantation to assess the feasibility of this strategy in the Chinese population. A method of rapid reduction of corticosteroid to 10 mg/day seven days post-transplantation was adopted for the experimental group, and the standard corticosteroid therapy for the control group. Comparison of intracellular ATP values detected two weeks post-transplantation for the control group (324 ± 45 ng/mL) and the experimental group (345 ± 91 ng/mL) did not reveal a significant difference (p > 0.05). The incidence of AR was analogous between groups (p > 0.05), while an increased incidence of infection was observed in the control group (53%) versus the experimental group (22%), where p < 0.05. The mean ATP concentration was lower in the control group (235 ± 35 ng/mL) than that of the experimental group (286 ± 16 ng/mL) when infection occurred (p < 0.05). The mean allograft function was similar between groups (p > 0.05). Rapid corticosteroid reduction early after kidney transplantation does not cause a significant rise in patient immunity or increase the incidence of AR, and contributes to infection control. This strategy may serve as a safe and effective therapy for kidney transplant patients in the Chinese population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplant Immunology - Volume 24, Issue 2, 15 January 2011, Pages 127-130
Journal: Transplant Immunology - Volume 24, Issue 2, 15 January 2011, Pages 127-130
نویسندگان
Shihai Li, Wei Wang, Xiaopeng Hu, Liang Ren, Hang Yin, Xiaoyong Yang, Hang Liu, Xiaodong Zhang,