کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6135815 1224904 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationA new vesicular compartment in Encephalitozoon cuniculi
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Short communicationA new vesicular compartment in Encephalitozoon cuniculi
چکیده انگلیسی

The microsporidia are emerging human and veterinary pathogens known to infect every tissue type and organ system. Their infectious spore possesses a number of peculiar organelles, including the diagnostic polar tube. In a proteomics-driven effort to find novel components of this organelle in the human-pathogenic species Encephalitozoon cuniculi, we unexpectedly discovered a protein which localizes to punctate structures consistent with the appearance of relic mitochondria, or mitosomes. However, this novel protein did not colocalize with ferredoxin, a mitochondrial iron-sulfur cluster protein which shows a similar localization pattern by light microscopy. The distribution pattern of this protein thus suggests either a novel vesicular compartment that is similar to mitosomes in size and distribution, the presence of subdomains or branching architecture within mitosomes, or heterogeneity in the protein composition of E. cuniculi mitosomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 14, Issue 4, April 2012, Pages 324-328
نویسندگان
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