کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6142525 | 1594368 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phylogeny and population dynamics of respiratory syncytial virus (Rsv) A and B
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کلمات کلیدی
HPDSUBsMEMESLACTMRCAMMLVGTRMCMCIFELRSVBSPMCCSBPFEL - UPSouth Africa - آفریقای جنوبیamino acid - آمینو اسیدOntario - انتاریوhighest posterior density - بالاترین تراکم خلفیBuenos Aires - بوئنوس آیرسphylogenetic analysis - تجزیه و تحلیل فیلوژنتیکSubstitutions - جایگزینیbase pairs - جفت پایهG protein - جی پروتئینmaximum clade credibility - حداکثر اعتبار کلاهtime of the most recent common ancestor - زمان آخرین جدیدترین اجداد مشترکgeneral time reversible - زمان عمومی برگشت پذیرMarkov chain Monte Carlo - زنجیره مارکف مونت کارلوSingle Likelihood Ancestor Counting - شمارش عادت تک عددیBayesian skyline plot - طرح خط افقی بیزیlower respiratory tract infections - عفونت های دستگاه تنفسی پایینBayes factor - فاکتور BayesSelective pressure - فشار انتخابیmixed effects model of evolution - مدل اثرات مخلوط تکاملEvolutionary rate - نرخ تکاملRespiratory syncytial virus - ویروس سنسیتیال تنفسیMoloney murine leukemia virus - ویروس لوئی موش MoloneyGARD - گارد
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants and young children. RSV is characterised by high variability, especially in the G glycoprotein, which may play a significant role in RSV pathogenicity by allowing immune evasion. To reconstruct the origin and phylodynamic history of RSV, we evaluated the genetic diversity and evolutionary dynamics of RSV A and RSV B isolated from children under 3 years old infected in Italy from 2006 to 2012. Phylogenetic analysis revealed that most of the RSV A sequences clustered with the NA1 genotype, and RSV B sequences were included in the Buenos Aires genotype. The mean evolutionary rates for RSV A and RSV B were estimated to be 2.1Â ÃÂ 10â3 substitutions (subs)/site/year and 3.03Â ÃÂ 10â3 subs/site/year, respectively. The time of most recent common ancestor for the tree root went back to the 1940s (95% highest posterior density-HPD: 1927-1951) for RSV A and the 1950s (95%HPD: 1951-1960) for RSV B. The RSV A Bayesian skyline plot (BSP) showed a decrease in transmission events ending in about 2005, when a sharp growth restored the original viral population size. RSV B BSP showed a similar trend. Site-specific selection analysis identified 10 codons under positive selection in RSV A sequences and only one site in RSV B sequences. Although RSV remains difficult to control due to its antigenic diversity, it is important to monitor changes in its coding sequences, to permit the identification of future epidemic strains and to implement vaccine and therapy strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 189, 30 August 2014, Pages 293-302
Journal: Virus Research - Volume 189, 30 August 2014, Pages 293-302
نویسندگان
Marianna Martinelli, Elena Rosanna Frati, Alessandra Zappa, Erika Ebranati, Silvia Bianchi, Elena Pariani, Antonella Amendola, Gianguglielmo Zehender, Elisabetta Tanzi,