کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6226376 1276379 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal Cannabis and Tobacco Exposure in Relation to Brain Morphology: A Prospective Neuroimaging Study in Young Children
ترجمه فارسی عنوان
مواجهه با سموم و سموم قبل از تولد در رابطه با مورفولوژی مغز: یک مطالعه چشمگیر چشم انداز در کودکان جوان
کلمات کلیدی
مورفولوژی مغز، تصویر برداری عصبی، توسعه مغز کودکان، مطالعات مبتنی بر جمعیت، قرار گرفتن در معرض کانابیس قبل از زایمان، قرار گرفتن در معرض تنباکو،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی

BackgroundCannabis use during pregnancy has been associated with negative behavioral outcomes and psychopathology in offspring. However, there has been little research evaluating alterations in brain structure as a result of maternal cannabis use. In this prospective study, we investigated the association between prenatal cannabis exposure and brain morphology in young children.MethodsWe matched 96 children prenatally exposed to tobacco only (without cannabis) with 113 unexposed control subjects on the basis of age and gender and subsequently selected 54 children exposed to prenatal cannabis (mostly combined with tobacco exposure). These children (aged 6 to 8 years) were part of a population-based study in the Netherlands, the Generation R Study, and were followed from pregnancy onward. We assessed brain volumetric measures and cortical thickness in magnetic resonance imaging scans using FreeSurfer. We performed vertexwise analyses in FreeSurfer and linear regression analyses adjusting for relevant covariates using Statistical Package for the Social Sciences.ResultsPrenatal cannabis exposure was not associated with global brain volumes, such as total brain volume, gray matter volume, or white matter volume. However, prenatal cannabis exposure was associated with differences in cortical thickness: compared with nonexposed control subjects, cannabis-exposed children had thicker frontal cortices. Prenatal tobacco exposure compared with nonexposed control subjects was associated with cortical thinning, primarily in the superior frontal and superior parietal cortices.ConclusionsOur findings suggest an association between prenatal cannabis exposure and cortical thickness in children. Further research is needed to explore the causal nature of this association.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychiatry - Volume 79, Issue 12, 15 June 2016, Pages 971-979
نویسندگان
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