Characteristics of behaviors and prepulse inhibition in phospholipase Cε−/− mice

BackgroundPhospholipase C (PLC) isozymes have been implicated in schizophrenia and may play a role in the disease process. Phospholipase Cε (PLCε) isozyme is an effector of Ras and Rap small GTPases and regulates intracellular signal transduction. Little is known about its role in signaling pathways in the central nervous system that mediate higher brain functions such as learning, memory and social behavior that are disrupted in schizophrenia.ObjectivesTo determine the effects of PLCε on social behavior, spatial memory and prepulse inhibition of acoustic (PPI) startle response in PLCε−/− mice.MethodsUsing a social interaction test, Morris water maze, and PPI.ResultsWe found that PLCε−/− mice showed increased social interactions and increased novelty-seeking exploratory behavior. Interestingly, PLCε−/− mice also showed improved performance on the Morris water maze task and enhanced PPI.ConclusionThese findings suggest that PLCε negatively regulates cognitive and social behaviors.