The retinoid, 6-[3-adamantyl-4-hydroxyphenyl]-2-napthalene carboxylic acid, controls proliferative, morphological, and inflammatory responses involved in microglial activation without cytotoxic effects

▶Microglia activation involves upregulated inflammatory responses and proliferation. ▶The retinoid, AHPN, controls cellular proliferation, differentiation, and death. ▶Effect of AHPN on inflammatory responses in LPS-activated microglial cultures. ▶Low concentration of AHPN reduced activation and proliferation with no cell death. ▶AHPN as a possible anti-inflammatory in neurodegenerative diseases.