کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282312 | 1615139 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord
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کلمات کلیدی
MDANox2STZNADPHROS - ROSHydrogen peroxide - آب اکسیژنهApocynin - آپوسیینینstreptozotocin - استرپتوزوتوسینNADPH oxidase - اکسیداز NADPH Diabetes - بیماری قندnormal saline - سالین نرمالSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازSpinal cord - طناب نخاعیmalondialdehyde - مالون دی آلدهیدNeuropathy - نوروپاتیnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateH2O2 - هیدروژن پراکسیدCurcumin - کورکومینReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are the main enzymes that produce oxidative stress, which plays an important role in painful diabetic neuropathy. Curcumin has been reported to exert an antinociceptive effect in a rat model of diabetic neuropathy by suppressing oxidative stress in the spinal cord. However, it remains unknown whether the mechanism by which curcumin ameliorates diabetic neuropathy can be attributed to spinal NADPH oxidases. This study was designed to determine the effect of curcumin on diabetic neuropathy and to investigate its precise mechanism in relation to NADPH oxidase-mediating oxidative stress in the spinal cord. Diabetic neuropathy was induced in Sprague-Dawley rats by intraperitoneal injection with 1% streptozotocin (STZ; 60Â mg/kg). After the onset of diabetic neuropathy, a subset of the diabetic rats received daily intragastric administrations of curcumin (200Â mg/kg) or intraperitoneal injections of apocynin (2.5Â mg/kg) for 14 consecutive days, whereas other diabetic rats received equivalent volumes of normal saline (NS). STZ resulted in diabetic neuropathy with hyperglycemia and a lower paw withdrawal threshold (PWT), accompanied by elevations in the expression of the NADPH oxidase subunits p47phox and gp91phox and in the levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA) and a reduction in superoxide dismutase (SOD) activity (PÂ <Â 0.05) in the spinal cord. Both curcumin and apocynin ameliorated diabetic neuropathy. In conclusion, curcumin attenuated neuropathic pain in diabetic rats, at least partly by inhibiting NADPH oxidase-mediating oxidative stress in the spinal cord.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 560, 7 February 2014, Pages 81-85
Journal: Neuroscience Letters - Volume 560, 7 February 2014, Pages 81-85
نویسندگان
Wei-Cheng Zhao, Bin Zhang, Mei-Juan Liao, Wen-Xuan Zhang, Wan-You He, Han-Bing Wang, Cheng-Xiang Yang,