کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6306304 | 1618808 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of cord blood BDNF in infant cognitive impairment induced by low-level prenatal manganese exposure: LW birth cohort, China
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کلمات کلیدی
GDIBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Iron - آهنEpidemiology - اپیدمیولوژی(همهگیرشناسی)intelligence quotient - بهره هوشیELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاMercury - جیوهLOD یا Limit of detection - حد تشخیصICP-MS - طیفسنجی جرمی پلاسمای جفتشده القاییinductively coupled plasma mass spectrometry - طیفسنجی جرمی پلاسمای جفتشده القاییBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزPrenatal exposure - قرار گرفتن در معرض پیش از قاعدگیlimit of detection - محدودیت تشخیصManganese - منگنز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study aimed to examine the potential association between low-level prenatal manganese (Mn) exposure and 1-year-old children's neurodevelopment quotient (DQ) by using the Gesell Developmental Inventory (GDI) (motor, adaptive, language, and social domains) and explored the role of brain-derived neurotrophic factor (BDNF) in Mn-induced cognitive impairments. A total of 377 mothers were recruited from a prospective birth cohort in rural northern China. Cord serum concentrations of Mn and BDNF were measured and children's DQ was evaluated. The median serum Mn concentration was 3.4 μg/L. After adjusting for confounding factors, Mn level was significantly associated with gross motor scores (β = â6.0, 95% CI: â11.8 to â0.2, p < 0.05) and personal-social scores (β = â4.2, 95% CI: â8.4 to 0.1, p < 0.05). BDNF level was positively correlated with personal-social score (β = 0.7, 95% CI: 0-1.4, p < 0.05). A significant correlation was found between Mn and BDNF (r = â0.13, 95% CI: â0.23 to â0.03, p < 0.01). Furthermore, the interaction between cord serum Mn and BDNF was significant (p < 0.001). In conclusion, elevated low-level prenatal Mn exposure impaired infant's neurodevelopment, and BDNF plays an important role in cognitive impairment, especially in the personal-social ability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 163, November 2016, Pages 446-451
Journal: Chemosphere - Volume 163, November 2016, Pages 446-451
نویسندگان
Xiaodan Yu, Limei Chen, Caifeng Wang, Xin Yang, Yu Gao, Ying Tian,