کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6309975 | 1618877 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations of organochlorine pesticides and polychlorinated biphenyls in visceral vs. subcutaneous adipose tissue with type 2 diabetes and insulin resistance
ترجمه فارسی عنوان
انجمن های آفت کش های ارگانو کلر و بیفنیل های پلی کربنات در بافت چربی زیر جلدی و با دیابت نوع 2 و مقاومت به انسولین
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کلمات کلیدی
DDTsdichlorodiphenyltrichloroethaneschlordanesCHLsORSHCBSATPCBsHCHs - HCH هاOrganochlorine pesticides - آفت کش های ارگانو کلرهPOPs - آلایندههای آلی دیرپاPersistent organic pollutants - آلایندههای آلی دیرپا(پایدار)Adipose tissue - بافت چربیvisceral adipose tissue - بافت چربی درشتSubcutaneous adipose tissue - بافت چربی زیر پوستیHexachlorobenzene - بنزن هگزاکلراید، هگزاکلروبنزنPolychlorinated biphenyls - بیفنیل پلیکلر Diabetes - بیماری قندLOD یا Limit of detection - حد تشخیصVAT - مالیات بر ارزش افزودهlimit of detection - محدودیت تشخیصInsulin resistance - مقاومت به انسولینodds ratios - نسبت شانسHexachlorocyclohexanes - هگزا کلروسیکوه هگزین ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Background exposure to organochlorine (OC) pesticides and polychlorinated biphenyls (PCBs) has been linked to type 2 diabetes. As OC pesticides and PCBs mainly accumulate in adipose tissue and there are physiological and clinical differences between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), we explored if there were associations of OC pesticides and PCBs in VAT or SAT with type 2 diabetes and insulin resistance. Participants were 50 patients with or without type 2 diabetes who underwent surgery for either cancer or benign liver or gallbladder lesions. We analyzed 14 OC pesticides and 22 PCB congeners in both VAT and SAT. Insulin resistance was estimated using homeostasis model assessment (HOMA). Although concentrations of OC pesticides and PCBs were strongly correlated between VAT and SAT, absolute concentrations differed substantially between them. In particular, concentrations of all PCBs were consistently about 5-10 times higher in VAT than SAT, but these patterns were independent of diabetes status. Some OC pesticides or PCBs, such as dichlorodiphenyltrichloroethanes (DDTs), chlordanes, and PCBs with 5 or less chlorides showed significant associations with diabetes or insulin resistance. For example, when tertiles of concentration-based summary measures were used, adjusted ORs were 1.0, 2.3, and 9.0 (P trend = 0.02) for DDTs in VAT and 1.0, 2.1, and 5.7 (P trend = 0.08) for PCBs with 5 or less chlorides. This study generally confirmed previous findings using serum concentrations. It would be useful to study pharmacodynamics of POPs in VAT and SAT further.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 94, January 2014, Pages 151-157
Journal: Chemosphere - Volume 94, January 2014, Pages 151-157
نویسندگان
Ki-Su Kim, Yu-Mi Lee, Sang Geol Kim, In-Kyu Lee, Hyo-Jeong Lee, Ji-Hyun Kim, Jeongkook Kim, Hyo-Bang Moon, David R. Jr., Duk-Hee Lee,