Modulation of immune-associated parameters and antioxidant responses in the crab (Scylla serrata) exposed to mercury

► A 14 d exposure of Hg induces physiological changes in the immune system of crab. ► The approach is based on utilizing the commercial crab Scylla serrata. ► Hg provokes immunomodulation, oxidative stress and antioxidant defences in crab. ► Correlation analysis between the responses was highly significant. ► First study to show Hg modulates immune functions and antioxidant system in crabs.