کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6352398 | 1622559 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human urinary/seminal phthalates or their metabolite levels and semen quality: A meta-analysis
ترجمه فارسی عنوان
فتالات ادرار / سموم انسان یا سطوح متابولیت آنها و کیفیت مایع منی: متاآنالیز
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کلمات کلیدی
MEHPDEPdibutyl phthalateLMWHMWBBzPDEHPDiDPTDMMBzPDnOPdi-n-octyl phthalateVSLMEHHPMEOHPstraight line velocityVCLMEPMMPCMRTRIMBPDBPDiNP - DINPmono(2-ethylhexyl) phthalate - mono (2-ethylhexyl) phthalateROS - ROSUnited States Environmental Protection Agency - آژانس حفاظت از محیط زیست ایالات متحدهThe European Union - اتحادیه اروپاEpidemiology - اپیدمیولوژی(همهگیرشناسی)butylbenzyl phthalate - بوتیل بنزیل فتالاتdi (2-ethylhexyl) phthalate - دی (2-اتیل هگزیل) فتالاتDiethyl phthalate - دی اتیل فتالاتdiisodecyl phthalate - دیاتیزیل فتالاتdiisononyl phthalate - دیونیزونیل فتالاتLinearity - رابطه خطی، خطی بودنWorld Health Organization - سازمان بهداشت جهانیCurvilinear velocity - سرعت چرخشیconfidence interval - فاصله اطمینانPhthalates - فتالاتMeta-analysis - فرا تحلیل Lin - لینToxics release inventory - موجودی انتشار توکسینmonoethyl phthalate - مونو اتیل فتالاتmonobenzyl phthalate - مونوبنسیل فتالاتmonobutyl phthalate - مونوبوتیل فتالاتMonomethyl phthalate - مونومیت مالت فتالاتodds ratio - نسبت شانس هاhigh molecular weight - وزن مولکولی بالاlow molecular weight - وزن مولکولی کمPVC - پلیوینیل کلراید یا پیویسیPolyvinyl chloride - کلرید پلی وینیلWHO - کهSemen quality - کیفیت اسپرمReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Health concerns surrounding human exposure to phthalates include diminished semen quality. Epidemiological findings remain inconsistent. We have performed a quality appraisal and meta-analysis to quantitatively summarize evidence for associations between phthalate exposures and human semen quality. Pubmed and Web of Science were searched for pertinent studies through October 2014. Cited references were reviewed to identify secondary studies. Studies that reported quantitative estimates of the association between phthalates or their metabolite levels in humans and semen quality were eligible. Random effects models were used to calculate pooled effects estimates. Overall, 20 studies met our inclusion criteria. Subsequently, 14 studies were included in the meta-analysis. Urinary monobutyl phthalate (MBP) and monobenzyl phthalate (MBzP) were associated with reduced sperm concentration (MBP [7.4-25.3 µg/L], pooled odds ratio [OR]=2.60, 95% confidence interval [CI]=1.32-5.15; MBzP [14.0-540.2 µg/L], pooled OR=2.23, 95% CI=1.16-4.30). Both MBP (24.6-14,459.0 µg/L) and MEHP (3.1-208.1 µg/L) were inversely associated with straight line velocity (VSL; MBP, pooled β=-2.51, 95% CI=-4.44, -0.59; MEHP, pooled β=-1.06, 95% CI=-1.99, -0.12). An IQR increase in MBzP and MEP levels (MBzP, IQR=11.35 µg/L; MEP, IQR=449.4 µg/L) was associated with an increase in comet extent (CE; MBzP, pooled β=3.57, 95% CI=0.89-6.25; MEP, pooled β=4.22, 95% CI=1.66-6.77). No associations were observed between monomethyl phthalate and any semen parameters. Our meta-analysis strengthens the evidence that specific phthalates or their metabolite levels may affect semen quality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 142, October 2015, Pages 486-494
Journal: Environmental Research - Volume 142, October 2015, Pages 486-494
نویسندگان
Hongquan Cai, Weiwei Zheng, Pai Zheng, Shu Wang, Hui Tan, Gengsheng He, Weidong Qu,