Immune responses to combined effect of hypoxia and high temperature in the green-lipped mussel Perna viridis

► Immune responses in haemocytes of Perna viridis was studied under hypoxic and temperature stresses. ► Est, ROS, Lyso and Pha were reduced at high temperatures. ► Hypoxia resulted in higher haemocyte mortality (HM) and reduced phagocytosis. ► Recovery from the stresses was observed for HM and Pha but not other immune responses.