کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6362734 | 1315695 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative sensitivity of harbour and grey seals to several environmental contaminants using in vitro exposure
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
اقیانوس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, we investigated the effects of cadmium chloride (CdCl2), mercury chloride (HgCl2), methylmercury chloride (CH3HgCl), and PCBs on lymphocyte proliferation in phocids. PBMCs isolated from harbour and grey seals were exposed in vitro to varying concentrations of contaminants. A reduction of viability occurred when cells were exposed to 10â4 M HgCl2 or CH3HgCl or to 50 ppm of Aroclor 1254. In both grey and harbour seals, T-lymphocyte proliferation was suppressed when their cells were incubated with 5 Ã 10â5 M CdCl2 or 10â4 M HgCl2. An inhibition of proliferation occurred with CH3HgCl from 10â6 M in grey seals and from 10â5 M in harbour seals. In grey seals, Aroclor 1254 reduced lymphocyte proliferation at 15 ppm. In both harbour and grey seals, CH3HgCl was ten times more immunotoxic that HgCl2. From IC50, chemicals were ranked in terms of toxicity as followed: CH3HgCl > CdCl2 > HgCl2 > Aroclor 1254.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Marine Pollution Bulletin - Volume 60, Issue 3, March 2010, Pages 344-349
Journal: Marine Pollution Bulletin - Volume 60, Issue 3, March 2010, Pages 344-349
نویسندگان
M.M. Dufresne, H. Frouin, S. Pillet, V. Lesage, S. De Guise, M. Fournier,