کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6486742 | 1222 | 2012 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FTIR spectro-imaging of collagens for characterization and grading of gliomas
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کلمات کلیدی
ECMInternal reflection elementIREATRGBMSNRECs - EC هاFpA - FPAFocal plane array - آرایه کانونی کانونیAngiogenesis - آنژیوژنزTotal internal reflection - بازتاب داخلی در کلAttenuated total reflectance - بازتاب کلی کاهش یافتهSynchrotron radiation - تابش سنکروترونFTIR imaging - تصویربرداری FTIRTIR - تیرCNS - دستگاه عصبی مرکزیnumerical aperture - دیافراگم عددیProtein structure - ساختار پروتئینBBB - سد خونی مغزیBlood–brain barrier - سد خونی مغزیCancer - سرطانEndothelial cells - سلولهای اندوتلیالcentral nervous system - سیستم عصبی مرکزیperipheral nervous system - سیستم عصبی پیرامونیFTIR - طیف سنج مادون قرمزBasal membrane - غشاء BasalFourier-transform infrared - فوریه تبدیل مادون قرمزExtracellular matrix - ماتریکس خارج سلولیSignal-to-noise ratio - نسبت سیگنال به نویزPNS - کارمندان دولتcollagens - کولاژن هاglioblastoma multiform - گلیوبلاستوما چندتایی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: FTIR spectro-imaging of collagens for characterization and grading of gliomas FTIR spectro-imaging of collagens for characterization and grading of gliomas](/preview/png/6486742.png)
چکیده انگلیسی
Collagens are a family of at least 30 protein types organized as networks. They constitute the main support material of cells under the form of extracellular matrix as well as for membranes in vessels, organs, and tissue compartments. Collagen network abnormalities are at the origin of many diseases, including myopathies and fibroses. The characterization of collagens remains an analytical challenge due to the insolubility of these molecules and the difficulty encountered in isolating given types without altering their structure or in maintaining network organization, which is critical to diagnosing related pathologies. We have proposed using a vibrational spectroscopy based imaging technique, namely Fourier-transform infrared (FTIR) imaging, for a spatially-resolved analysis of secondary structure of different collagen types in complex samples, and more specifically for characterizing gliomas. With newly developed spectral data treatments and chemometrics using secondary structure parameters of collagen proteins, FTIR imaging is now able to distinguish between several types. On this basis, gliomas have been investigated as specific collagen-rich tissues developing in a non-collagenous environment, providing high specificity to this FTIR imaging utilization. Here, we review the recent advances in this imaging approach for understanding glioma development, with FTIR imaging now being proposed as a molecular histopathology tool for clinicians.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 30, Issue 6, NovemberâDecember 2012, Pages 1432-1446
Journal: Biotechnology Advances - Volume 30, Issue 6, NovemberâDecember 2012, Pages 1432-1446
نویسندگان
Razia Noreen, Michel Moenner, Yeukuang Hwu, Cyril Petibois,