کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6490507 | 43365 | 2016 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fermentation scale up for α-arbutin production by Xanthomonas BT-112
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fermentation scale up for α-arbutin production by Xanthomonas BT-112 Fermentation scale up for α-arbutin production by Xanthomonas BT-112](/preview/png/6490507.png)
چکیده انگلیسی
α-Arbutin is a glycosylated hydroquinone that has an inhibitory function against tyrosinase. The aim of the present study is to develop an efficient and inexpensive method for large-scale production of α-arbutin by using Xanthomonas BT-112 as biocatalyst. To accomplish this goal, various surfactants were tested to enhance the α-arbutin production, and the optimal operational conditions for 30 L jar fermenter were scaled up for a production level of 3000 L with using a constant volumetric oxygen transfer coefficient (KLa) and the volumetric aeration rate per volume unit (Q/V) as scale-up criteria. Under the optimized conditions, the α-arbutin produced in the presence of 0.4% (w/v) Tween-80 was 124.8% higher than that of the control, and the yield of α-arbutin in 3000 L fermenter was 38.2 g/L with a molar conversion ratio of 93.7% based on the amount of hydroquinone supplied. This result is comparable to the results from laboratory-scale fermenter. Hence, 100-fold scale-up was successfully achieved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biotechnology - Volume 233, 10 September 2016, Pages 1-5
Journal: Journal of Biotechnology - Volume 233, 10 September 2016, Pages 1-5
نویسندگان
Meng Wei, Yi Ren, Changxia Liu, Ruican Liu, Peng Zhang, Yi Wei, Tao Xu, Fang Wang, Tianwei Tan, Chunqiao Liu,