Bcl-xL overexpression delays the onset of autophagy and apoptosis in hyperosmotic recombinant Chinese hamster ovary cell cultures

► Hyperosmolality in CHO cell cultures induces autophagy and apoptosis. ► Bcl-xL overexpression delays autophagy/apoptosis in hyperosmotic CHO cell cultures. ► Bcl-xL overexpression improves cell viability and EPO production at hyperosmolality.