Effect of low-level laser irradiation on proliferation of human dental mesenchymal stem cells; a systemic review

There is limited evidence that in-vitro LLLI (660/810/980 nm, with energy densities of 0.1-3 J/cm2) increases the proliferation of DMSCs. Considering the limited evidence and their method heterogeneity it is difficult to reach a firm conclusion. Further research is necessary to identify the optimal characteristics of the LLLI setting (wave length, energy density, power output, frequency/duration of irradiations, distance between the cells and the laser spot/probe) to increase proliferation of DMSCs, and assess its impact on replicative senescence, as well as determine feasibility of the use in the clinical setting.