Modulations of gene expression induced by daily ultraviolet light can be prevented by a broad spectrum sunscreen

► We studied gene expression in reconstructed skin exposed to daily UV radiation DUVR. ► Protective effect of a broad spectrum sunscreen face to DUVR was assessed. ► DUVR led to modulation of genes that were related to essential cutaneous functions. ► The sunscreen was highly effective in protecting reconstructed skin against DUVR.