Lipase-immobilized magnetic chitosan nanoparticles for kinetic resolution of (R,S)-ibuprofen

- Chitosan-poly[N-benzyl-2-(methacryloxy)-N,N-dimethyl-ethanaminium bromide] coated magnetic nanoparticles were prepared.
- High enantioselectivity of kinetic resolution of (R,S)-ibuprofen was obtained with the use of lipase-immobilized chitosan magnetic nanoparticles.
- The sulfo-NHS/EDC-activated magnetic particles provide easy recovery and reuse of lipase.
- Baseline resolution obtained for all analyzed compounds using chiral stationary phases.