کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6538091 | 1421010 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antioxidant and anticancer activities of Plectranthus stocksii Hook. f. leaf and stem extracts
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
جنگلداری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The properties of Plectranthus stocksii-a well-known folk medicinal plant-were investigated. The plant extracts were successively extracted and tested for phytochemicals using high performance liquid chromatography, while antioxidant and anticancerous properties were assessed using MCF-7, Caco-2 and RAW 264.7 cancerous cell line models. The methanolic extract of leaves showed higher concentrations of total phenolics (415.41 mg gallic acid equivalents/g extract) and tannins (177.53 mg gallic acid equivalents/g extract) contents than other studied extracts. In the case of flavonoids, ethyl acetate extract of leaf (LEA) showed a higher concentration (777.11 mg rutin equivalents/g extract) and was also found to have better antioxidant activity against stable radical 2,2-diphenylpicrylhydrazyl (3.46 μg/mL), 2,2â²azinobis (3-ethylbenzothiozoline-6-sulfonic acid) disodium salt radical (27.41 mM Trolox equivalent/g extract) and superoxide (24.16 μg/mL) radicals and showed better IC50 (the concentration of the sample at which the inhibition rate reaches 50%) values on MCF-7 (48.874 μg/mL) and Caco-2 (36.088 μg/mL) cancerous cell line models. The immense anti-oxidant potential of P. stocksii leaf and stem extracts could be utilized as a good source of natural, anti-oxidant supplement in food to defend against oxidative-stress-related disorders and more generally in the food safety industry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Agriculture and Natural Resources - Volume 51, Issue 2, April 2017, Pages 63-73
Journal: Agriculture and Natural Resources - Volume 51, Issue 2, April 2017, Pages 63-73
نویسندگان
Kasipandi Muniyandi, Elizabeth George, Vekataramana Mudili, Naveen Kumar Kalagatur, Allen Joseph Anthuvan, Kadirvelu Krishna, Parimelazhagan Thangaraj, Gopalan Natarajan,