کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6555976 | 1422505 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ãvaluation du rôle de l'aflatoxine B1 dans l'apparition du carcinome hépatocellulaire en Côte d'Ivoire : étude préliminaire
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی قانونی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ãvaluation du rôle de l'aflatoxine B1 dans l'apparition du carcinome hépatocellulaire en Côte d'Ivoire : étude préliminaire Ãvaluation du rôle de l'aflatoxine B1 dans l'apparition du carcinome hépatocellulaire en Côte d'Ivoire : étude préliminaire](/preview/png/6555976.png)
چکیده انگلیسی
Hepatocellular carcinoma (HCC) is a major cause of cancer death in sub-Saharan Africa. The main etiologic agents of this pathology are chronic infection with hepatitis B virus (HBV) and dietary exposure to aflatoxin B1. This work is the preliminary step of a study that aimed to assessment the involvement of aflatoxin B1 in the development of hepatocellular carcinoma in Côte d'Ivoire. Thirty-three HCC patients and 66 controls (33 cases of chronic HBV and 33 blood donors) were recruited for this study. The aflatoxin B1-lysine biomarker was extracted and purified from the serum on anion exchange columns and quantified using an HPLC system coupled to a fluorescent detector. Aflatoxin B1-lysine was found in 81.82% of CHC patients and 78.79% of controls. The mean levels of aflatoxin B1-lysine were 36.57 pg/mg albumin in HCC patients, 34.95 pg/mg albumin in HBV patients and 25.63 pg/mg albumin in blood donors. No significant difference was found between aflatoxin B1-lysine levels in HCC and control patients (P > 0.05). The synergistic effect between aflatoxins and HBV could be a significant risk factor in the development of HCC in Côte d'Ivoire.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicologie Analytique et Clinique - Volume 30, Issue 2, June 2018, Pages 85-95
Journal: Toxicologie Analytique et Clinique - Volume 30, Issue 2, June 2018, Pages 85-95
نویسندگان
Pierre Manda, Aholia Jean-Baptiste Adépo, Alphonsine Kouassi M'bengue, Michel Konan, Jean Verdier N'gbe, Moussa Doumbia, Toussaint Toutou, Sébastien Djédjé Dano,