کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6829603 | 547990 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The PIP5K2A gene and schizophrenia in the Chinese population - A case-control study
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Results from a number of molecular and pharmacological studies suggest that the phosphatidylinositol-4-phosphate 5-kinase IIα (PIP5K2A) gene may be involved in the development of schizophrenia. A recent family-based transmission disequilibrium test in the German and Israeli populations found that four single nucleotide polymorphisms, rs1417374, rs10828317, rs746203 and rs8341 in this gene or nearby intergenic regions are significantly associated with schizophrenia. The objective of our study was to investigate whether these four SNPs are also associated with schizophrenia in the Chinese population. Our study found that SNP rs8341 (p = 0.0045, Odds Ratio = 1.415, 95%CI = 1.113-1.799 for the minor allele) and a haplotype (p = 0.0039, Odds Ratio = 1.440, 95%CI = 1.123-1.845) are significantly associated with schizophrenia. Our results confirm that the PIP5K2A gene merits further study as a susceptible gene for schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 94, Issues 1â3, August 2007, Pages 359-365
Journal: Schizophrenia Research - Volume 94, Issues 1â3, August 2007, Pages 359-365
نویسندگان
ZangDong He, ZhiQiang Li, YongYong Shi, Wei Tang, Ke Huang, Gang Ma, Jian Zhou, JunWei Meng, HuaFang Li, GuoYing Feng, Lin He,