One-pot chemoenzymatic synthesis of chiral disubstituted 1,2,3-triazoles in aqueous media

• 1,3-Dipolar cycloaddition reaction and bioreduction with carrot bits in one-pot.
• Excellent enantiomeric excesses were obtained for all reactions (>99%).
• Only water as solvent was needed for all reactions.
• Cheap catalysts were employed.

A one-pot, two-step procedure combining 1,3-dipolar cycloaddition and an enantioselective reduction mediated by Daucus carota (carrot root) is described. The synthesis was accomplished by first employing the biocatalyst followed by a “click” reaction under very mild conditions to yield the corresponding chiral disubstituted 1,2,3-triazoles.

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