Saccharomyces cerevisiae catalyzed one pot synthesis of isoindolo[2,1-a]quinazoline performed under ultrasonication

An efficient and simple one pot method has been developed for the synthesis of isoindolo[2,1-a]quinazolines using Saccharomyces cerevisiae (baker's yeast) as a whole cell biocatalyst at room temperature. The synergetic effect of baker's yeast and ultrasound irradiation has been discussed.

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► This is the first report for the synthesis of title compounds using biocatalysis.
► Simultaneous application of sonic waves and baker's yeast resulted in greater efficiency in terms of reaction time and yield.
► The role of baker's yeast in the reaction mechanism has also been studied.
► The effects of various factors on the yield of target components were investigated.