کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7280325 | 1473912 | 2016 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress
ترجمه فارسی عنوان
کمبود گیرنده های فراکتالکین پاسخ های میکروگلالیال و نورون به استرس مزمن را مختل می کند
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کلمات کلیدی
Chronic stress - استرس مزمنMajor depression - افسردگی شدیدLTP - تقویت طولانی مدت یا LTP Differential susceptibility - حساسیت دیفرانسیلLife events - رویدادهای زندگیPhagocytosis - فاگوسیتوز یا بیگانهخواری Environment - محیط زیستMicroglia - میکروگلیاهاPlasticity - پلاستیکfractalkine receptor - گیرنده فراتلکین
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Chronic stress is one of the most relevant triggering factors for major depression. Microglial cells are highly sensitive to stress and, more generally, to environmental challenges. However, the role of these brain immune cells in mediating the effects of stress is still unclear. Fractalkine signaling - which comprises the chemokine CX3CL1, mainly expressed by neurons, and its receptor CX3CR1, almost exclusively present on microglia in the healthy brain - has been reported to critically regulate microglial activity. Here, we investigated whether interfering with microglial function by deleting the Cx3cr1 gene affects the brain's response to chronic stress. To this purpose, we housed Cx3cr1 knockout and wild-type adult mice in either control or stressful environments for 2Â weeks, and investigated the consequences on microglial phenotype and interactions with synapses, synaptic transmission, behavioral response and corticosterone levels. Our results show that hampering neuron-microglia communication via the CX3CR1-CX3CL1 pathway prevents the effects of chronic unpredictable stress on microglial function, short- and long-term neuronal plasticity and depressive-like behavior. Overall, the present findings suggest that microglia-regulated mechanisms may underlie the differential susceptibility to stress and consequently the vulnerability to diseases triggered by the experience of stressful events, such as major depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 55, July 2016, Pages 114-125
Journal: Brain, Behavior, and Immunity - Volume 55, July 2016, Pages 114-125
نویسندگان
Giampaolo Milior, Cynthia Lecours, Louis Samson, Kanchan Bisht, Silvia Poggini, Francesca Pagani, Cristina Deflorio, Clotilde Lauro, Silvia Alboni, Cristina Limatola, Igor Branchi, Marie-Eve Tremblay, Laura Maggi,