کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7281177 | 1473922 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Total and differential white blood cell counts, high-sensitivity C-reactive protein, and cardiovascular risk in non-affective psychoses
ترجمه فارسی عنوان
تعداد کل گلبولهای سفید خون سفید، پروتئین واکنش پذیر با حساسیت بالا و خطر قلبی عروقی در روانپزشکی غیر عاطفی
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کلمات کلیدی
Risk assessment - ارزیابی ریسکSchizophrenia - اسکیزوفرنی یا شیزوفرنیinflammation - التهاب( توروم) cardiovascular disease - بیماری قلب و عروقیNon-affective psychosis - روانشناسی غیر عاطفیLymphocytes - لنفوسیت هاLeukocytes - لکوسیتMonocytes - مونوسیتهاNeutrophils - نوتروفیل هاC-reactive protein - پروتئین واکنشی سی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Schizophrenia is associated with increased cardiovascular disease morbidity and mortality. Schizophrenia is also associated with immune and inflammatory abnormalities, including aberrant blood levels of lymphocytes, cytokines and high-sensitivity C-reactive protein (hsCRP). The purpose of this study is to investigate the relationship between total and differential white blood cell (WBC) counts, hsCRP, and indices of cardiovascular disease risk in patients with schizophrenia and related non-affective psychoses. 108 inpatients and outpatients age 18-70 with non-affective psychoses and 44 controls participated in this cross-sectional study. Subjects had a fasting blood draw between 8 and 9 am for glucose, lipids, total and differential WBC counts, and hsCRP. Vital signs and medical history were obtained. Patients with non-affective psychosis had significantly higher hsCRP levels than controls (p = 0.04). In linear regression analyses, lymphocyte and monocyte counts were a significant predictor of the total-to-HDL cholesterol ratio in subjects with non-affective psychosis (p ⩽ 0.02 for each). In binary logistic regression analyses, total WBC count was a significant predictor of an elevated 10-year estimated risk of myocardial infarction and cardiovascular disease in subjects with non-affective psychosis (p ⩽ 0.03 for each). Associations between total and differential WBC counts and cardiovascular disease risk indices were stronger in males than females with non-affective psychosis. Our findings provide further evidence that measurement of total and differential WBC counts may be germane to the clinical care of patients with schizophrenia and related disorders, and support an association between inflammation and cardiovascular disease risk in these patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 45, March 2015, Pages 28-35
Journal: Brain, Behavior, and Immunity - Volume 45, March 2015, Pages 28-35
نویسندگان
Brian J. Miller, Prianka Kandhal, Mark Hyman Rapaport, Andrew Mellor, Peter Buckley,