کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7610011 | 1493473 | 2016 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of rifampicin as a chiral selector for enantioresolution of basic drugs using capillary electrophoresis
ترجمه فارسی عنوان
استفاده از ریفامپیسین به عنوان یک انتخاب کیرال برای انانیت رزاسیون داروهای پایه با استفاده از الکتروفورز مویرگی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Rifampicin, a member of rifamycin sub-class of antibiotics which belongs to the naphthalenic ansamycin class of antibiotics, has a characteristic ansa structure, i.e., a ring structure or chromophore spanned by an aliphatic chain. The present work was designed to evaluate its potential as a chiral selector (CS) as its structure consisting of nine stereogenic centers, an aromatic moiety and several functional groups (i.e., one imine, one amide, one acetoxy residue, two aliphatic hydroxyl and three phenolic hydroxyl groups) was expected to instigate multiple enantioselective interactions, namely, hydrogen bonding and inclusion complexation with chiral analytes, and therefore resulting in efficient enantioseparations. Systematic experiments were performed to investigate the effects of concentration of CS, composition of background electrolyte (BGE) and applied voltage on chiral separation. Enantiomers of propranolol and metoprolol were baseline resolved using a BGE consisting of 20Â mM CS and 50/50 (v/v) iso-propanol/phosphate buffer (100Â mM, pH 7.0) whereas for enantiomers of sertraline, a BGE consisting of 23Â mM CS and 40/60 (v/v) iso-propanol/phosphate buffer (100Â mM, pH 7.0) resulted in baseline resolutions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1453, 1 July 2016, Pages 138-142
Journal: Journal of Chromatography A - Volume 1453, 1 July 2016, Pages 138-142
نویسندگان
Shuchi Dixit, Jung Hag Park,