کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7622772 1494525 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Branched-chain amino acid ratios modulate lipid metabolism in adipose tissues of growing pigs
ترجمه فارسی عنوان
نسبت های آمینو اسید زنجیره ای مدولاسیون متابولیسم لیپیدها را در بافت های چربی خوک های در حال رشد ایجاد می کند
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The effects and roles of branched-chain amino acid (BCAAs) ratios in lipid metabolism in adipose tissues of pigs are still unkown. We used pigs (Large White × Landrace, 35 ± 2 d) to investigate the effects of varying BCAA ratios (Leu: Ile: Val = 1:1:1, 1:0.75:0.75, 1:0.51:0.63, 1:0.25:0.25) on growth, carcass traits, and fat metabolism in adipose tissues. Results showed that as the ratio declined, the weight of total fat mass reduced while the adiponectin concentrations increased (P < .05), with the lowest/highest values observed in the 1:0.25:0.25 group, respectively. Moreover, varying BCAA ratios modulated the expression of genes related to adipose tissue function (P < .05). Concomitant with these changes, the 1:0.25:0.25 group increased/decreased the phosphorylation of AMPKα/mTOR, respectively (P < .05). The mRNA abundance of PGC-1α and IL-15 were also increased in diets with BCAA ratios from 1:0.75:0.75 to 1:0.25:0.25. Our data suggest that dietary BCAA ratios in the adequate range, i.e. 1:0.75:0.75-1:0.25:0.25, modulate adipose tissue function including fatty acid synthesis, transport, and oxidation, lipolysis, and adipokine secretion. These effects are partly mediated by AMPK-mTOR pathway and associated with mitochondrial biogenesis, the AMPK-PGC-1α axis, and IL-15 secreted by muscle tissues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 614-624
نویسندگان
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