کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7628582 1645353 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease
ترجمه فارسی عنوان
اثر درمان کاهش کلسترول بر روی مارکرهای پلاسمای اختلال عملکرد اندوتلیال در بیماری مزمن کلیه
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The elevated cardiovascular morbidity and mortality in chronic kidney disease (CKD) is linked with endothelial dysfunction secondary to the pro-inflammatory and pro-oxidative state typical of this pathology. In consideration of the well-known pleiotropic effect of statins, we investigated the effect of cholesterol lowering treatment on endothelial dysfunction markers (MED), asymmetric dimethylarginine (ADMA), vascular cell (VCAM) and intercellular (ICAM) adhesion molecule. Plasma MED concentrations, inflammation and oxidative stress indices [Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA) and allantoin/uric acid (All/UA) ratio] were measured in 30 CKD patients randomized to three cholesterol lowering regimens for 12 months (simvastatin 40 mg/day, ezetimibe/simvastatin 10/20 mg/day, or ezetimibe/simvastatin 10/40 mg/day). Treatment significantly reduced ADMA concentrations in all patients [0.694 μmol/L (0.606-0.761) at baseline vs. 0.622 μmol/L (0.563-0.681) after treatment, p < 0.001]. ADMA reduction was paralleled by a significant decrease of MDA, All/AU ratio and Kyn/Trp ratio, but not VCAM and ICAM plasma concentrations. Cholesterol lowering treatment was associated with a significant reduction in plasma ADMA concentrations in CKD patients. This might be mediated by reduced oxidative stress and inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 129, 10 September 2016, Pages 383-388
نویسندگان
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