A validated liquid chromatography tandem mass spectrometry method for quantification of erlotinib, OSI-420 and didesmethyl erlotinib and semi-quantification of erlotinib metabolites in human plasma

- A validated LC-MS/MS method for quantification of erlotinib and its metabolites.
- Analysis suitable for TDM and clinical studies.
- Identification of fourteen HLM generated metabolites, three not previously reported.