کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7692034 | 1496261 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Topical treatments with acylceramide dispersions restored stratum corneum lipid lamellar structures in a reconstructed human epidermis model
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کلمات کلیدی
SDSSAXSEOHdihydrosphingosineRHEphytosphingosineLPPEoPSPPTEWLTransepidermal water loss - از دست دادن آب دریچهsphingosine - اسپینگوزینReconstructed human epidermis - اپی ادیس انسانی بازسازی شدهTem - این استLamellar structure - ساختار لایه ایsodium dodecyl sulfate - سدیم دودسیل سولفاتEOs - عناوینlong periodicity phase - فاز دوره ای طولانیStratum corneum - لایه شاخی، استراتوم کورنئومskin barrier - مانع پوستیTransmission electron microscopy - میکروسکوپ الکترونی عبوریX-ray diffraction - پراش اشعه ایکسSmall-angle X-ray scattering - پراکندگی اشعه ایکس با زاویه کوچکIntercellular lipid - چربی بین سلولی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Long-periodicity phase (LPP) lamellar structures in intercellular lipid matrixes of the stratum corneum (SC) are considered important for maintenance of skin permeability barriers. Acylceramides are essential components of LPP structures, and their absence influences skin barriers under physiological and pathological conditions, such as atopic dermatitis and dry skin. Although topical applications of acylceramide have been shown to facilitate maintenance of the skin barrier, it is unknown whether topically applied acylceramides are incorporated into intercellular lipids to form LPP structures. Thus, we assessed the effects of topical treatments with monomodal acylceramides on the formation of LPP structures in a surfactant-insulted reconstructed human epidermis model using small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) analyses. In SAXS experiments, LPP structures give rise to a diffraction peak which indicates the presence of a structure with a 13â¯nm real space repeat distance. LPP patterns of intercellular lipid matrixes in the SC were disrupted' by surfactant treatments and were recovered by topical acylceramide treatments. TEM images also showed specific repeating patterns of LPP structures, indicating that topical acylceramide treatments facilitate recovery of LPP structures in the SC. The present data show that the application of acylceramides might temporarily modify the lipid structure to resemble that of normal skin although the underlying cause of dry or diseased skin is not fully clarified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 215, September 2018, Pages 56-62
Journal: Chemistry and Physics of Lipids - Volume 215, September 2018, Pages 56-62
نویسندگان
Akina Nakaune-Iijima, Akinori Sugishima, Gen Omura, Hiroyuki Kitaoka, Tomoko Tashiro, Shigeki Kageyama, Ichiro Hatta,