کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7784388 | 1500576 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chitosan oligosaccharide-N-chlorokojic acid mannich base polymer as a potential antibacterial material
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کلمات کلیدی
Ethyl alcohol (PubChem CID: 702)N,N-Dimethylformamide (PubChem CID: 6228)Deuterium oxide (PubChem CID: 24602)Glacial acetic acid (Pubchem CID: 176)Acetone (PubChem CID: 180) - استون (PubChem CID: 180)Kojic acid - اسید کجیکChitosan oligosaccharide - الیگوساکارد کیتوزانAntibacterial material - مواد ضد باکتریSodium hydroxide (PubChem CID: 14798) - هیدروکسید سدیم (PubChem CID: 14798)Mannich reaction - واکنش منیچPyridine (PubChem CID: 1049) - پیریدین (PubChem CID: 1049)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Here, a nontoxic antibacterial material based on Chitosan Oligosaccharide-N-Chlorokojic acid Mannich base (COS-N-MB) that was synthesized by using the selective partial alkylation reaction displaying excellent activity against bacterial infection. The proposed mechanism of the action of COS-N-MB is that this antibacterial material with positive charge and synergistic antibacterial effects can promote it's adsorption to bacterial cell wall through electrostatic interaction and chelating metal cations. It changed the permeability of the membrane, caused cellular leakage, and destroyed the membrane integrity, leading to complete membrane disruption and eventually death of the bacteria. Besides, COS-N-MB can interact with membrane proteins, causing deformation in the structure and functionality. The good biocompatibility, noncytotoxic, and low hemolysis made this novel material a promising and effective compound for antibacterial applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 182, 15 February 2018, Pages 225-234
Journal: Carbohydrate Polymers - Volume 182, 15 February 2018, Pages 225-234
نویسندگان
Xiaoli Liu, Wenshui Xia, Qixing Jiang, Peipei Yu, Lin Yue,