MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways

► MiR-350 over-expressed through p38 and JNK protein synthesis. ► MiR-350 led to an increase in unphosphorylated NFATc3. ► Antagomir-350 could lower the levels of miR-350. ► Antagomir-350 could reverse the expression of target proteins. ► MiR-350 is a critical regulator of pathological cardiac hypertrophy and apoptosis.