Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia

► Ezetimibe glucuronidation is a biomarker for UGT1A1 activity in vivo. ► Ezetimibe glucuronidation correlates with reduction of serum bilirubin in Gunn rats. ► Ezetimibe glucuronidation in the Gunn rat is affected by gender. ► Bilirubin glucuronides in bile confirm efficacy of gene therapy for inherited jaundice.