Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease

► Evaluation of the toxic effects of dopamine quinones (DAQ) on mitochondria. ► A very diverse reactivity was observed for the different DAQ investigated. ► DAQ triggers the opening of the permeability transition pore. ► DAQ induce oxidation of NADH, while GSH levels are not affected.