کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8295117 | 1536757 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi](/preview/png/8295117.png)
چکیده انگلیسی
A 75 kDa serine protease having prolyl oligopeptidase activity has been purified from Setaria cervi, a bovine filarial parasite. The MALDI-MS/MS analysis of the purified protein revealed 6 peptides showing nearest match S9A (prolyl oligopeptidase) family protein from Plesiocystis pacifica. The ScPOP was found to be unique compared to mammalian POP with respect to its kinetic properties. To elucidate its role, filarial parasites were exposed to specific inhibitor of POP, Z-Pro-prolinal (ZPP) for 8â¯h. The inhibition of POP induced calcium signaling via phospholipase c stimulation which further triggered mitochondrial mediated apoptosis in filarial parasites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 495, Issue 3, 15 January 2018, Pages 2235-2241
Journal: Biochemical and Biophysical Research Communications - Volume 495, Issue 3, 15 January 2018, Pages 2235-2241
نویسندگان
Mohit Wadhawan, Savitri Tiwari, Shweta Sharma, Sushma Rathaur,