کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8295117 1536757 2018 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi
چکیده انگلیسی
A 75 kDa serine protease having prolyl oligopeptidase activity has been purified from Setaria cervi, a bovine filarial parasite. The MALDI-MS/MS analysis of the purified protein revealed 6 peptides showing nearest match S9A (prolyl oligopeptidase) family protein from Plesiocystis pacifica. The ScPOP was found to be unique compared to mammalian POP with respect to its kinetic properties. To elucidate its role, filarial parasites were exposed to specific inhibitor of POP, Z-Pro-prolinal (ZPP) for 8 h. The inhibition of POP induced calcium signaling via phospholipase c stimulation which further triggered mitochondrial mediated apoptosis in filarial parasites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 495, Issue 3, 15 January 2018, Pages 2235-2241
نویسندگان
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