Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice

► DGAT1 deficiency on an ApoE-null background reduces diet-induced atherosclerotic lesion formation. ► DGAT1 deficiency decreases cholesterol uptake and absorption in ApoE-null mice. ► Reduced macrophage migration and decreased aortic inflammation in ApoE-null mice lacking DGAT1. ► Increased cholesterol efflux from macrophages lacking DGAT1. ► Additional potential application of DGAT1 inhibitors with regard to attenuating atherosclerosis.