Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain

► Dietary n-6 PUFA deprivation downregulated cPLA2 and COX-2 in rat brain. ► Dietary n-6 PUFA deprivation upregulated iPLA2 and 15-LOX in rat brain. ► These changes are opposite to n-3 PUFA deprivation in rat brain. ► These changes would tend to maintain homeostasis of brain AA and DHA function.