Keywords: Cardiovascular diesease; Dipeptidyl peptidase 4 inhibitor; Atherosclerosis; Heart failure; Myocardial infarction; AMI; acute myocardial infarction; BNP; Brain natriuretic peptide; CD26; cluster of differentiation 26; CHD; coronary heart disease; CKD; chro
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Keywords: 2-AG; 2-arachidonoylglycerol; β; standardized partial regression coefficient; FAAH; fatty acid amide hydrolase; FNT; fenitrothion; MNP; 3-methyl-4-nitrophenol; OP; organophosphate; R2; coefficient of determination adjusted for the degrees of freedom; sPL
Keywords: Panx; pannexin; CBX; carbenoxolone; PBNC; probenecid; Adip; adiponectin; AR; AdipoRon; AC; acid ceramidase; NC; neutral ceramidase; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; CKD; chronic kidney disease; DAMP; damage-associated molecular patte
Keywords: acute coronary syndrome; anti-inflammatory; drug targets; ACS; acute coronary syndromes; CABG; coronary artery bypass graft; CAD; coronary artery disease; HDL-C; high-density lipoprotein cholesterol; hsCRP; high-sensitivity C-reactive protein; IL; interle
Keywords: AFM; Atomic Force Microscopy; ARDS; Acute Respiratory Distress Syndrome; ATI; Alveolar Type I (cell); ATII; Alveolar Type II (cell); CBS; Captive Bubble Surfactometer; CPAP; Continuous Positive Airway Pressure; CRP; C-reactive Protein; DPPC; Dipalmitoylph
Keywords: PL; phospholipids; sPLA2; secreted phospholipase A2; CC-PLA2; Cerastes cerastes venom phospholipase A2; MVL-PLA2; Macrovipera lebetina transmediterranea; 1,2 DLPC; l-2 dilauroyl-sn-glycero-3-phosphatidylcholine; 1,2 DLPE; l-2dilauroyl-sn-glycero-3-phospha
Keywords: Inflammation; Biosensors; sPLA2; Conjugated linoleic acid; sIgA; IL-10;
Keywords: Phospholipid asymmetry; Lysophosphatidic; Platelet-activating factor; Phosphoinositides; PLRP2; Phospholipase B; 2-AG; 2-arachidonoyl-glycerol; ATX; autotaxin; cPLA2; cytosoluble phospholipase A2; DAG; diacylglycerol; ECs; endocannabinoids; IP3; inositol
Keywords: EPO; evening primrose oil; LCFAs; long chain fatty alcohols; LPS; lipopolysaccharide; GC; gas chromatography; GC-MS; gas chromatography-mass spectrometry; NO; nitric oxide; iNOS; inducible nitric oxide; TXB2; thrombaxane E2; PGE2; prostaglandine E2; T
In silico investigation of the molecular effects caused by R123H variant in secretory phospholipase A2-IIA associated with ARDS
Keywords: Molecular dynamics simulation; sPLA2; PLA2G2A gene; Molecular modelling; Electrostatic potential;
Multiple mechanisms underlying neuroprotection by secretory phospholipase A2 preconditioning in a surgically induced brain injury rat model
Keywords: SBI; surgical brain injury; PLA2; phospholipase A2; PPC; PLA2 preconditioning; 5-LOX; 5-lipoxygenase; AA; arachidonic acid; LTB4; leukotriene-B4; BWC; brain water content; WBC; white blood cells; GFAP; glial fibrillary acidic protein; MPO; myeloperoxidase
Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages
Keywords: ONS; oxidative/nitrosative stress; TLR; toll-like receptor; LPS-EK (Ultrapure); lipopolysaccharide from E. coli K12; TLR4-WT macrophages; macrophages derived from wild-type mice; TLR4-KO macrophages; macrophages derived from complete TLR4 knock-out mice;
Molecular docking and in vitro studies of soap nut trypsin inhibitor (SNTI) against phospholipase A2 isoforms in therapeutic intervention of inflammatory diseases
Keywords: PLA2; Allelochemicals; SNTI; Homology modeling; Docking; Protein interaction; sPLA2;
Functional characterization and FTIR-based 3D modeling of full length and truncated forms of Scorpio maurus venom phospholipase A2
Keywords: Sm-PLGV; phospholipase A2 purified from Scorpio maurus venom glands.; rPLA2(+5); recombinant phospholipase A2 containing the whole gene transcript either long and short chains linked by the penta-peptide.; rPLA2(â5); recombinant phospholipase A2 in whic
Borage oil restores acidic skin pH by up-regulating the activity or expression of filaggrin and enzymes involved in epidermal lactate, free fatty acid, and acidic free amino acid metabolism in essential fatty acid-deficient Guinea pigs
Keywords: Borage oil; Skin pH; Lactate; Free fatty acids; Acidic free amino acids; Guinea pig; BO; borage oil; EFA; essential fatty acid; EFAD; essential fatty acid deficiency; FFA; free fatty acid; FAA; free amino acid; GCase; β-glucocerebrosidase; GLA; γ-linole
Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
Keywords: AA; arachidonic acid; AMPK; AMP-dependent protein kinase; ATGL; adipose triglyceride lipase; cPLA2α; cytosolic group IVA PLA2; CPT1; carnitine O-palmitoyltransferase 1; CPT1A; the liver isoform of CPT1; DGAT1; diacylglycerol acyltransferase 1; DHA; docos
The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis
Keywords: ACAT; Acyl-CoA:cholesterol acyltransferase; ADAM17; a disintegrin and metalloproteinase 17; APO; apolipoprotein; COL18; collagen XVIII; CS/DS; chondroitin sulfate/dermatan sulfate; FLOT1; flotilin-1; GLCE; C5 epimerase; GPIHBP1; glycosylphosphatidylinosit
Lipid metabolism in Rhodnius prolixus: Lessons from the genome
Keywords: 4CL; 4-coumarate:CoA ligase; ACS; acyl-CoA synthetases; ACSBG; ACS bubblegum; ACSL; ACS long-chain; ACSM; ACS medium-chain; ACSS; ACS short-chain; ACSVL; ACS very long-chain; Bmm; brummer; iPLA2; calcium-independent PLA2; CPT; carnitine palmitoyltransfera
Oleic acid-derived oleoylethanolamide: A nutritional science perspective
Keywords: ABHD4; α/β-hydrolase domain-containing protein 4; AEA; arachidonoylethanolamide; A:G; android-to-gynoid; CHO; carbohydrate; DHEA; docosahexaenoylethanolamide; DXA; dual-energy X-ray absorptiometry; E; energy; EEA; elaidoylethanolamide; FAAH; fatty acid
Effect of prenatal steroidal inhibition of sPLA2 in a rat model of preterm lung
Keywords: Preterm neonate; Rat; Secretory phospholipase A2; Steroids; Surfactant; ARDS; acute respiratory distress syndrome; lyso-PEA; lysophosphatidylethanolamine; PEA; phosphatidylethanolamine; lyso-PC; lysophosphatidylcholine; PC; phosphatidylcholine; PBS; phosp
Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils
Keywords: Eosinophil; leukotriene; phospholipase A2; mitogen-activated kinase; asthma; allergy; 5-LO; 5-Lipoxygenase; cPLA2α; Cytosolic phospholipase A2α; CysLT; Cysteinyl leukotriene; DMSO; Dimethyl sulfoxide; ER; Endoplasmic reticulum; ERK1/2; Extracellular-sig
Expression, purification, refolding, and enzymatic characterization of two secretory phospholipases A2 from Neurospora crassa
Keywords: CD; circular dichroism; ESI-MS; electrospray ionization mass spectrometry; His6; hexahistidine; LPC; lysophosphatidylcholine; LPE; lysophosphatidylethanolamine; NDSB; non-detergent sulfobetain; ORF; open reading frame; PC; phosphatidylcholine; PE; phospha
Effects of vipoxin and its components on HepG2 cells
Keywords: Vipoxin; sPLA2; HepG2 cells; Cytotoxicity; Apoptosis
A constant area monolayer method to assess optimal lipid packing for lipolysis tested with several secreted phospholipase A2
Keywords: ACN; acetonitrile; CHCA; hydroxycynnamic acid (α-cyano-4-hydroxycinnamic acid); DLPC; dilauroyl phosphatidylcholine; LR20/10; lipolytic hydrolysis ratio taken at 20 and 10 mN·mâ 1 measured by either isochoric or isobaric mode; MALDI; matrix-assisted
Neutrophil effector responses are suppressed by secretory phospholipase A2 modified HDL
Keywords: C5a; complement component 5a; FFA; free fatty acid; fMLP; N-formyl-l-methionyl-l-leucyl-l-phenylalanine; HDL; high-density lipoprotein; ICAM-1; intracellular adhesion molecule-1; IL-8; interleukin 8; NET; neutrophil extracellular traps; LPC; lysophosphati
Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells
Keywords: AMs; alveolar macrophages; ARDS; Acute Respiratory Distress Syndrome; BAL; bronchoalveolar lavage; C12-NBD-FA; 12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoic acid; C12-NBD-PC; 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-
PKCδ-iPLA2-PGE2-PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells
Keywords: CLDN1; claudin 1; TJ; tight junctions; PPARγ; peroxisome proliferator-activated receptor γ; TRAF-2; TNF-associated factor 2; FADD; Fas-associated protein with death domain; sPLA2; secreted phospholipase 2; cPLA2; cytosolic calcium dependent PLA2; iPLA2;
sPLA2 and the epidermal barrier
Keywords: Lipids; pH; Secretory phospholipase; sPLA2; Stratum corneum; Permeability barrier
Renaturation and one step purification of the chicken GIIA secreted phospholipase A2 from inclusion bodies
Keywords: Phospholipase A2; Gene expression; In vitro refolding; sPLA2; secreted phospholipase A2; ChPLA2-IIA; chicken intestinal PLA2;
Probing selected structural regions in the secreted phospholipase A2 from Arabidopsis thaliana for their impact on stability and activity
Keywords: Secreted phospholipase A2 from Arabidopsis thaliana; Trp variants; Structure-stability relationship; Activity; N-Terminal deletion; AtPLA2α; sPLA2α from Arabidopsis thaliana; bpPLA2; sPLA2 from bovine pancreas; bvPLA2; sPLA2 from bee venom; DOPC; 1,2-
Cancer Stem Cell Phenotype Is Supported by Secretory Phospholipase A2 in Human Lung Cancer Cells
Keywords: ALDH; aldehyde dehydrogenase; ALDH-high; aldehyde dehydrogenase high cells; ALDH-low; aldehyde dehydrogenase low cells; CSC; cancer stem cell; FACS; flow-assisted cell sorting; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; RT-PCR; reverse transcriptase
Antibacterial properties of recombinant human non-pancreatic secretory phospholipase A2
Keywords: PLA2; phospholipase A2; sPLA2; secretory phospholipase A2; hnpsPLA2; human non-pancreatic secretory phospholipase A2; Human non-pancreatic secretory phospholipase A2; Bactericidal activity; Gram-positive bacteria; Gram-negative bacteria; pH;
Class specific peptide inhibitors for secretory phospholipases A2
Keywords: AMP; antimicrobial peptides; bv; bee venom; C28-O-PHPM; 1-octosanyl-2-(pyren-1-yl)hexanoyl-sn-glycero-3-phospho-monomethyl ester; cPLA2; cytosolic PLA2; CSSP; continuum secondary structure predictor; EM; electron microscopy; FFA; free fatty acid; Hsp70; h
Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo
Keywords: DHA; Docosahexaenoic acid; AA; Arachidonic acid; LA; Linoleic acid; α-LNA; α-linolenic acid; DPA; Docosapentaenoic acid; EDP; Epoxy-docosapentaenoic acid; EPA; Eicosapentaenoic acid; PLA2; Phospholipase A2; cPLA2; Cytosolic PLA2; sPLA2; Secretory PLA2;
Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency
Keywords: LTs; leukotrienes; LTB4; leukotriene B4; cysLTs; cysteinyl leukotrienes; PLA2; phospholipase A2; sPLA2; secretory PLA2; cPLA2; group IV PLA2; HPETEs; hydroperoxyeicosatetraenoic acids; HETEs; hydroxyeicosatetraenoic acids; CF; cystic fibrosis; Af; Aspergi
Emerging roles of secreted phospholipase A2 enzymes: An update
Keywords: Phospholipase A2; Lipid; Arachidonic acid; Atherosclerosis; Inflammation; DHA; docosahexaenoic acid; DPA; docosapentaenoic acid; DRG; dorsal root ganglion; GI; gastrointestinal; LDL; low-density lipoprotein; LXR; liver X receptor; LPS; lipopolysaccharide;
Identification of novel phospholipase A2 group IX members in metazoans
Keywords: GIX phospholipase A2; GXIV phospholipase A2; Conserved domain; Pfam09056; PLA2; phospholipase A2; sPLA2; secreted phospholipase A2; GIX PLA2; group IX phospholipase A2; GXII PLA2; group XII phospholipase A2; GXIV PLA2; group XIV phospholipase A2; cd; cons
Recognition of Vipera ammodytes meridionalis neurotoxin vipoxin and its components using phage-displayed scFv and polyclonal antivenom sera
Keywords: Vipoxin; sPLA2; Phage display library; Single-chain antibody variable fragments (scFv); ELISA;
Kinetic properties of pancreatic and intestinal sPLA2 from chicken and mammals using the monomolecular film technique
Keywords: sPLA2; secreted phospholipase A2; ChPLA2-IB; chicken pancreatic sPLA2; ChPLA2-IIA; chicken intestinal sPLA2; pPLA2-IB; porcine pancreatic sPLA2; hPLA2-IIA; human intestinal sPLA2; β-CD; β-cyclodextrin; 1,2 DDPC; l-2 didodecanoyl-sn-glycero-3-phosphatidy
Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain
Keywords: AA; arachidonic acid; DHA; docosahexaenoic acid; DPA; docosapentaenoic acid; PUFA; polyunsaturated fatty acid; cPLA2; cytosolic phospholipase A2; sPLA2; secretory PLA2; iPLA2; Ca2+-independent PLA2; COX; cyclooxygenase; SREBP; sterol regulatory element bi
Identification of presynaptic neurotoxin complexes in the venoms of three Australian copperheads (Austrelaps spp.) and the efficacy of tiger snake antivenom to prevent or reverse neurotoxicity
Keywords: Snake presynaptic phospholipase A2 neurotoxin; Austrelaps; Australian copperhead; Snake antivenom; Neurotoxicity; Neurotransmitter release; ACh; acetylcholine; ANOVA; analysis of variance; BCA; bicinchoninic acid; BSA; bovine serum albumin; CBCNM preparat
Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy
Keywords: ABCA-1/G-1; ATP-binding cassette transporter A-1/G-1; ACAT-1; Acyl-CoA:cholesterol acyltransferase-1; AcLDL; acetylated LDL; ADRP; adipocyte differentiation related protein; ApoE/A-I; apolipoprotein E/A-I; BMMs; bone-marrow derived macrophages; CD; cl
Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer's disease pathology
Keywords: 2-AG; 2-arachidonoylglycerol; 4-HNE; 4-hydroxynonenals; 4-HHE; 4-hydroxyhexenal; AA; arachidonic acid; Aβ; β-amyloid; ADAM; A Disintegrin And Metalloprotease; ADAPT; Alzheimer's Disease Anti-inflammatory Prevention trial; AD; Alzheimer's disease; AE
Effect of the synthetic coumarin, ethyl 2-oxo-2H-chromene-3-carboxylate, on activity of Crotalus durissus ruruima sPLA2 as well as on edema and platelet aggregation induced by this factor
Keywords: Crotalus durissus ruruima; Edema; Myonecrosis; Platelet; sPLA2; Synthetic coumarinCK, creatine kinase; EOCC, ethyl 2-oxo-2H-chromene-3-carboxylate; 7-HOC, 7-hydroxycoumarin; pBPB, p-bromophenacyl bromide; PLA2, phospholipase A2; sPLA2, secretory phosholip
Extracellular phospholipases in atherosclerosis
Keywords: Lp-PLA2; PAF-AH; sPLA2; PLA2GX; Atherogenesis; Inflammation
A biophysical approach to phospholipase A2 activity and inhibition by anti-inflammatory drugs
Keywords: sPLA2; NSAIDs; Enzymatic inhibition; Membrane model systems; Membrane biophysical properties;
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)
Keywords: Abh4; α/β-hydrolase 4; 2-AG; 2-arachidonoylglycerol; Ca-NAT; Ca2+-dependent NAT; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; COX; cyclooxygenase; DTT; dithiothreitol; FAAH; fatty acid amide hydrolase; GDE; glycerophosphodiesteras
Association with actin mediates the EGTA-resistant binding of cytosolic phospholipase A2-α to the plasma membrane of activated platelets
Keywords: Platelet; Phospholipase A2; Plasma membrane; Actin; cPLA2α; Cytosolic phospholipase A2-α; PLA2; phospholipase A2; iPLA2; Calcium-independent phospholipases A2; sPLA2; Secretory phospholipases A2; AA; Arachidonic acid; TxA2; Thromboxane A2; CalB; Calcium
Secreted phospholipases A2: A proinflammatory connection between macrophages and mast cells in the human lung
Keywords: AA; arachidonic acid; Akt; protein kinase B; BA; bronchial asthma; BAL; bronchoalveolar lavage; BBMCs; bone marrow-derived mast cells; COPD; chronic obstructive pulmonary disease; ERK1/2; extracellular-regulated kinase 1/2; HSPG; heparan sulfate proteogly
Lung mast cells are a source of secreted phospholipases A2
Keywords: Lung mast cells; secreted phospholipase A2; leukotriene C4; arachidonic acid; BALF; Bronchoalveolar lavage fluid; BMMC; Bone marrow-derived mast cell; cPLA2; Cytosolic phospholipase A2; Ct; Cycle threshold; DTT; Dithiothreitol; GAPDH; Glyceraldehyde-3-p