کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553424 | 1562587 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epididymal phospholipidosis is a possible mechanism for spermatotoxicity induced by the organophosphorus insecticide fenitrothion in rats
ترجمه فارسی عنوان
فسفولیپیدوز اپیدیدیم یک مکانیسم احتمالی سمیت اسپرماتوژنیک ناشی از فنیتروتیون حشرهکش ارگانوفسفره در موش صحرایی است
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کلمات کلیدی
FAAHFNTMNPsPLA22-arachidonoylglycerol2-AGVIF3-Methyl-4-nitrophenol - 3-متیل-4-نیوتروفنلOrganophosphate - ارگانوفسفاتFatty acid amide hydrolase - اسید آمینه هیدرولاز اسید چربstandard deviation - انحراف معیارEpididymis - اپیدیدیم، روخاگ، بربخterminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling - ترمینال دگزا کینوکلئوتیدیل ترانسفراز - dUTP نهایی پایان نامهTUNEL - تونلVariance inflation factor - فاکتور تورم واریانسFenitrothion - فریتروتیونSecreted phospholipase A2 - فسفولیپاز A2 تثبیت شدهphospholipidosis - فسفولیپیدوز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent male accessory sex organs. The present study aimed to reveal the effects of FNT on the accessory organs of rats exhibiting spermatotoxicity in the absence of testicular histopathological changes. Furthermore, a possible novel molecular target was clarified. Male Wistar rats were orally administered 5 or 10â¯mg/kg FNT or its major metabolite 3-methyl-4-nitrophenol (MNP), or vehicle only, 4â¯days per week for 9 weeks. Then the epididymis, prostate, and seminal vesicles were collected. FNT and MNP did not show anti-androgenic effects but FNT induced cytoplasmic vacuolation in the epithelial cells of epididymal ducts and hyperplasia of mucosal folds/epithelial papillomatosis in seminal vesicles. FNT and MNP induced epididymal phospholipidosis, which was presumably caused by inhibition of epididymal secreted phospholipase A2 (sPLA2). Percentages of morphologically normal sperm and immature sperm were significantly predicted from both epididymal sPLA2 and phospholipid levels and from epididymal sPLA2, respectively. These results suggest that epididymal phospholipidosis plays an important role in FNT-induced spermatotoxicity. Anti-androgenic actions were not observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 285, 15 March 2018, Pages 27-33
Journal: Toxicology Letters - Volume 285, 15 March 2018, Pages 27-33
نویسندگان
Mio Miyake, Yuki Ito, Himiko Suzuki, Motohiro Tomizawa, Hirotaka Sato, Ming Liu, Ai Okamura, Tamie Nakajima, Katsumi Ohtani, Hisashi Takino, Hiroshi Inagaki, Michihiro Kamijima,