کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336292 | 1540610 | 2018 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-alcoholic fatty liver disease severity and metabolic complications in obese children: impact of omega-3 fatty acids
ترجمه فارسی عنوان
شدت بیماری کبد چرب غیر الکلی و عوارض متابولیک در کودکان چاق: اثر اسید چرب امگا 3
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EPAOXSNAFLDMDAoxLDLFLIIMTCTRLDL-CRBCVLCFADBPSBPGGTOxidized LDL - LDL اکسید شدهγ-Glutamyl transferase - γ-گلوتامیل ترانسفرازapo - آپوapolipoprotein - آپولیپوپروتئینEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکPolyunsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعFatty acids - اسیدهای چربinflammation - التهاب( توروم) interleukin - اینترلوکینcardiovascular disease - بیماری قلب و عروقیnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیTriglycerides - تریگلیسریدOxidative stress - تنش اکسیداتیوDHA - دوکوساهگزائنوئیک اسیدCVD - رسوب دهی شیمیایی بخار Metabolic syndrome - سندرم متابولیکbody mass index - شاخص توده بدنBMI - شاخص توده بدنیfatty liver index - شاخص کبد چربIntima-media thickness - ضخامت Intima-mediadiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکmalondialdehyde - مالون دی آلدهیدMETS - متسInsulin resistance - مقاومت به انسولینGas chromatography - کروماتوگرافی گازیLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمControl - کنترلred blood cell - گلبول قرمز، اریتروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Although n-3 polyunsaturated fatty acids (PUFA) revealed promising therapeutic results in non-alcoholic fatty liver disease (NAFLD), which is considered as the most prevalent cause of chronic hepatic disease, inconsistencies are calling for further confirmatory trials to demonstrate therapeutic efficacy and safety. The study, registered as NCT02201160 on www.clinicaltrials.gov, was designed to compare two groups of NAFLD with a different severity, and to evaluate the efficacy of n-3 PUFA supplementation. Twenty young male participants of French Canadian origin with NAFLD were enrolled and classified into moderate (mNAFLD) and severe (sNAFLD) fatty liver groups, according to transaminase levels, ultrasonography, NAFLD Activity Score and Fatty Liver Index (FLI). The sNAFLD patients were assigned to consume 2 g of n-3 PUFA for 6 months. sNAFLD patients displayed higher insulinemia, insulin resistance (IR), oxidative stress (OxS), systolic blood pressure and the risk lipid indicators of cardiovascular diseases. Supplementation of n-3 PUFA for 6 months resulted in a significant increase in concentrations of eicosapentaenoic and docosahexaenoic acids in red blood cells along with an attenuation of hepatic steatosis as reflected by the reduction of the FLI, ALT and ALT/AST ratio. Moreover, the n-3 PUFA improved the lipid profile and carotid intima-media thickness, while reducing metabolic and OxS markers as well as raising adiponectin. In conclusion, NAFLD severity was essentially related to IR. Treatment with n-3 PUFA has an evidently beneficial effect on liver steatosis and related metabolic abnormalities. Furthermore, the cross association of omega-3 index with cardiometabolic markers may serve as a predictor for cardiovascular risk disorders in NAFLD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 58, August 2018, Pages 28-36
Journal: The Journal of Nutritional Biochemistry - Volume 58, August 2018, Pages 28-36
نویسندگان
Schohraya Spahis, Fernando Alvarez, Nejma Ahmed, Josée Dubois, Ramy Jalbout, Massimiliano Paganelli, Kelly Grzywacz, Edgard Delvin, Noel Peretti, Emile Levy,