کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8346048 | 1541625 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide
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کلمات کلیدی
Nω-monomethyl-l-arginineHPLC-ECDnNOSIFN-γIL-1βSGCiNOSNOScGMPRARNG-nitro-l-arginine methyl esterNox2L-NMMAPTMTNFαGTPPGCRNOS8-Nitro-cGMPLPS2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide - 2- (4-کاربوکسی فنیل) -4،4،5،5-تترامتییلیمیدازولین-1-اکسیل -3 اکسیدkeap1 - buy1MPO - DFOcPTIO - eptirguanosine 3′,5′-cyclic monophosphate - guanosine 3 '، 5'-cyclic monophosphatel-NAME - L-NAMELC–MS/MS - LC-MS / MSNADPH oxidase 2 - NADPH اکسیداز 2neuronal NOS - NOS عصبیinducible NOS - NOS قابل القاییNOx - NOXROS - ROSadenosine 5′-triphosphate - آدنوزین 5'-تری فسفاتATP - آدنوزین تری فسفات یا ATPMyocardial infarction - آنفارکتوس میوکاردpost-translational modification - اصلاح post-translationalNADPH oxidase - اکسیداز NADPH interferon-γ - اینترفرون-γInterleukin-1β - اینترلوکین-1βtumor necrosis factor α - تومور نکروز عامل αSOD - سدNitric oxide synthases - سنتز اکسید نیتروژنSuperoxide dismutase - سوکسوکس دیسموتازlipopolysaccharide - لیپوپلی ساکاریدmyeloperoxidase - میلوپراکسیداز Kelch-like ECH-associated protein 1 - پروتئین مرتبط با ECH کلچ 1Liquid chromatography with tandem mass spectrometry - کروماتوگرافی مایع با طیف سنجی جرمی دو طرفهguanosine 5′-triphosphate - گوانوزین 5'-تری فسفاتReactive nitrogen oxide species - گونه اکسید نیتروژن واکنش پذیرReactive oxygen species - گونههای فعال اکسیژنRetinoic acid receptor - گیرنده اسید رتینوئیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
8-Nitroguanosine 3â²,5â²-cyclic monophosphate (8-nitro-cGMP) is a unique derivative of guanosine 3â²,5â²-cyclic monophosphate (cGMP) formed in mammalian and plant cells in response to production of nitric oxide and reactive oxygen species. 8-Nitro-cGMP possesses signaling activity inherited from parental cGMP, including induction of vasorelaxation through activation of cGMP-dependent protein kinase. On the other hand, 8-nitro-cGMP mediates cellular signaling that is not observed for native cGMP, e.g., it behaves as an electrophile and reacts with protein sulfhydryls, which results in cGMP adduction to protein sulfhydryls (protein S-guanylation). Several proteins have been identified as targets for endogenous protein S-guanylation, including Kelch-like ECH-associated protein 1 (Keap1), H-Ras, and mitochondrial heat shock proteins. 8-Nitro-cGMP signaling via protein S-guanylation of those proteins may have evolved to convey adaptive cellular stress responses. 8-Nitro-cGMP may not undergo conventional cGMP metabolism because of its resistance to phosphodiesterases. Hydrogen sulfide has recently been identified as a potent regulator for metabolisms of electrophiles including 8-nitro-cGMP, through sulfhydration of electrophiles, e.g., leading to the formation of 8-SH-cGMP. Better understanding of the molecular basis for the formation, signaling functions, and metabolisms of 8-nitro-cGMP would be useful for the development of new diagnostic approaches and treatment of diseases related to oxidative stress and redox metabolisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 34, 1 November 2013, Pages 10-18
Journal: Nitric Oxide - Volume 34, 1 November 2013, Pages 10-18
نویسندگان
Tomohiro Sawa, Hideshi Ihara, Tomoaki Ida, Shigemoto Fujii, Motohiro Nishida, Takaaki Akaike,