کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8471087 | 1550062 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns
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کلمات کلیدی
SyntenyIn situ hybridization - Hybridization در محلinflammation - التهاب( توروم) Innate immunity - ایمنی ذاتیTissue regeneration - بازسازی بافتGene expression - بیان ژنphylogenetic analysis - تجزیه و تحلیل فیلوژنتیکRepair - تعمیرMolecular evolution - تکامل مولکولیGene family - خانواده ژنیRecombination - دوباره سازیDevelopment - رشدEmbryonic development - رشد رویانTranscription - رونویسیFish - ماهیVertebrates - مهره دارانChromatin - کروماتینHigh-mobility group - گروه تحرک بالاDanio rerio - گورخرماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns](/preview/png/8471087.png)
چکیده انگلیسی
The High-Mobility Group Box (HMGB) proteins are highly abundant proteins with both nuclear and extracellular roles in key biological processes. In mammals, three family members are present: HMGB1, HMGB2 and HMGB3. We characterized the HMGB family in zebrafish and report a detailed phylogenetic analysis of HMGB proteins. The B1, B2, and B3 subfamilies are present in cartilaginous fish, bony fish, and tetrapods, while jawless fish sequences emerge as basal to the gene family expansion. Two co-orthologs of each mammalian HMGB gene are present in zebrafish. All six zebrafish hmgb genes are maternally expressed, but huge differences in expression levels exist during embryonic development. The hmgb2a/hmgb2b genes are the most highly expressed, while hmgb3b is expressed at the lowest level. Remarkably, hmgb3 genes are not present in fugu, medaka, Tetraodon and stickleback. Our analysis highlights substantial overlaps, but also subtle differences and specificities in the expression patterns of the zebrafish hmgb genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 11, Issues 1â2, JanuaryâFebruary 2011, Pages 3-11
Journal: Gene Expression Patterns - Volume 11, Issues 1â2, JanuaryâFebruary 2011, Pages 3-11
نویسندگان
Silvia Moleri, Giuseppe Cappellano, Germano Gaudenzi, Solei Cermenati, Franco Cotelli, David S. Horner, Monica Beltrame,