کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8485768 | 1551750 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monitoring the efficacy of infant hepatitis B vaccination and revaccination in 0- to 8-year-old children: Protective anti-HBs levels and cellular immune responses
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کلمات کلیدی
FCMPBMCHBeAgHBsAgHBIGTFHHepatitis B surface antigen - آنتی ژن سطحی هپاتیت BImmunogenicity - ایمنی زاییLymphocyte subsets - زیر مجموعه های لنفوسیتperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیT follicular helper cell - سلول کمکی فولیکولVaccine failure - شکست واکسنanti-HBc - ضد HBcAnti-HBe - ضد HBeAnti-HBs - ضد HBsFlow cytometry - فلوسیتومتریHepatitis B e antigen - هپاتیت B آنتی ژنhepatitis B immunoglobulin - هپاتیت B ایمونوگلوبولینHBV - هپاتیت بhepatitis B virus - ویروس هپاتیت بی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vaccination against hepatitis B virus (HBV) is recommended worldwide. The aim of this study was to assess the efficacy of infant hepatitis B vaccination and revaccination in 0- to 8-year-old children in the context of protective anti-HBs levels and cellular immune responses. Using a random questionnaire survey, 1695 pre-school children were recruited as research subjects during January 2015 to June 2017. Blood samples were obtained to measure HBV serological markers as well as peripheral immunocytes. The children were divided into non-, low- and hyper- responsive groups (NR, LR, and HR) based on the vaccination efficacy. Additionally, the effect of revaccination on the NR group was evaluated at 1â¯month after completion of the vaccination course. Among a total of 1695 children, 1591 (93.86%) were infants who were followed while undergoing their primary course of hepatitis B vaccination at the 0-1-6â¯month schedule, and 1249 (79.30%) of them developed antibodies against HBsAg (anti-HBs) titers greater than 10â¯IU/L. The results of immunocyte studies indicated that the CD8+ T cells, CD4+CD45RO+ T cells, CD8+CD45RA+ T cells, and T follicular helper (Tfh) cells increased significantly in NR compared with HR. However, lymphocytes, CD4+ T cells, and CD4+CD45RA+ T cells in NR were lower than that in HR. 96 of the non-response cases showed seroprotection after revaccination among 103 cases. Therefore, most of the preschool children who received hepatitis B vaccine in infancy achieved significant seroprotection. Seroconversion rates of individuals revaccinated after initial vaccination failure were significantly higher than those after primary vaccination. Different vaccination efficacy groups showed significant changes in circulating immunocytes, which might be a factor affecting the recombinant HBV vaccine's immune effectiveness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 36, Issue 18, 25 April 2018, Pages 2442-2449
Journal: Vaccine - Volume 36, Issue 18, 25 April 2018, Pages 2442-2449
نویسندگان
Xuefen Li, Yumiao Xu, Yuejiao Dong, Xianzhi Yang, Bo Ye, Yiyin Wang, Yu Chen,