کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8492931 | 1552791 | 2018 | 53 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The protective role of glutamine on enteropathy induced by high dose of soybean meal in turbot, Scophthalmus maximus L.
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کلمات کلیدی
AMPKMLCKPCoAZO-1SBMGLNILIAla-GlnIL-1βZonula occluden-1SGRMUC-2PPAR-γTGF-βNF-κBUPGMAADCOTU - OTadenosine 5′-monophosphate-activated protein kinase - آدنوزین 5'-monophosphate-فعال پروتئین کینازAlanyl-glutamine - آلانیل گلوتامینAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییISI - آی اس آیEnteropathy - انتروپاتیFER - انجام دهیدInterleukin-1β - اینترلوکین-1βtransforming growth factor-β - تبدیل فاکتور رشد βprinciple coordinate analysis - تجزیه و تحلیل اصل مختصاتTurbot - توربوtumor necrosis factor-α - تومور نکروز عامل αAKP - حزب عدالت و توسعهDAO - دائوDiamine oxidase - دیامین اکسیدازGoblet cell - سلول گوبلApparent digestibility coefficient - ضریب هضم ظاهریTNF-α - فاکتور نکروز توموری آلفاNuclear factor-kappa B - فاکتور هسته ای-کاپا BLamina propria - لامینا پروپریاIntestinal mucosal barrier - مانع مخاطی رودهFeed intake - مصرف غذاmucin-2 - موین-2Intestinal microbiota - میکروبیای روده یا باکتری های روده ایSurvival rate - نرخ بقاspecific growth rate - نرخ رشد خاصfeed efficiency ratio - نسبت بازده خوراکoperational taxonomic unit - واحد تاکسونومی عملیاتیFish meal - وعده ماهیSoybean meal - کنجاله سویاMyosin light-chain kinase - کیناز زنجیره سبک مایوسینglutamine - گلوتامینPeroxisome proliferator-activated receptor-γ - گیرنده پروتئینی فعال پروکسیوم - γ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study is to investigate the protective effect and regulatory mechanism of Gln on the enteropathy of turbot induced by soybean meal. Three isonitrogenous and isolipidic practical diets were formulated with fish meal basis (FM), soy protein replacing 40% fish meal protein (SBM) and dietary 2% Ala-Gln in SBM (Ala-Gln) for sextuple replicates of 30 fish each tank for 12â¯weeks. The fish in SBM group presented distinct enteropathy including declined absorptive surface and overt infiltration of mixed leukocytes in the lamina propria. However, the turbot fed Ala-Gln diet showed the integrity of the intestinal tissue structure and higher ADC and AKP levels like fish in FM group. Compared to SBM group, the inclusion of 2% Ala-Gln in SBM-basal diet significantly elevated the expression of barrier-forming tight junction proteins claudin-4, occludin and ZO-1 and depressed the expression of pro-inflammatory cytokines TNF-α in the intestine. Fish fed Ala-Gln diet showed remarkable increased MUC-2 and PPAR-γ gene expression as well as reduced expression of NF-κB and MLCK equivalent to the level of FM group. Additionally, Gln significantly elevated the relative abundance of Proteobacteria (Vibrio spp.) and declined Bacteroidetes (Bacteroides spp.) relative abundance. The similarity of intestinal microbial communities in Ala-Gln group was notably closer to FM group from PCoA, UPGMA and Heatmap analyses based on weighted UniFrac distance. In conclusion, dietary Gln could probably enhance intestinal barrier function to alleviate enteropathy by improving MUC-2 and PPAR-γ expression and inhibiting NF-κB-MLCK signaling pathway, as well as altering microbiota.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquaculture - Volume 497, 1 December 2018, Pages 510-519
Journal: Aquaculture - Volume 497, 1 December 2018, Pages 510-519
نویسندگان
Yang Liu, Zhichu Chen, Jihong Dai, Pei Yang, Haibin Hu, Qinghui Ai, Wenbing Zhang, Yongan Zhang, Yanjiao Zhang, Kangsen Mai,